Cytoplasmic delivery of functional siRNA using pH-Responsive nanoscale hydrogels
نویسندگان
چکیده
منابع مشابه
pH-sensitivity of fast responsive superporous hydrogels.
Stimuli-sensitive hydrogels (or smart hydrogels) are hydrogels that swell or shrink in response to small changes in environmental conditions in which they are placed. While the extent of swelling or shrinking may be large, the kinetics of such changes is slow, since the diffusion of water into and out of the hydrogel is a slow process. To obtain fast responses, we have prepared superporous hydr...
متن کاملMulti-responsive supramolecular hydrogels for drug delivery.
We reported in this study a versatile method to prepare multi-responsive supramolecular hydrogels for drug delivery application.
متن کاملResponsive pentablock copolymers for siRNA delivery
In this study, temperature and pH responsive cationic and amphiphilic pentablock copolymers, which consist of the temperature responsive triblock Pluronic F127 sandwiched between pH responsive PDEAEM (poly(2-diethylaminoethyl methacrylate)) end blocks, were used for the first time in the development of polyplex and gold nanoparticle (AuNP) based multicomponent siRNA delivery systems (MCSs). Cop...
متن کاملTargeted Delivery of siRNA with pH-Responsive Hybrid Gold Nanostars for Cancer Treatment
In this work, we report the engineering of gold nanostars (GNS) to deliver small interfering RNA (siRNA) into HepG2 cells. The ligand DG-PEG-Lipoic acid (LA)-Lys-9R (hydrazone) was designed to functionalize GNS, and create the nanoparticles named as 9R/DG-GNS (hydrazone). In the ligand, 2-deoxyglucose (DG) is the targeting molecule, polyethylene glycol (PEG) helps to improve the dispersity and ...
متن کاملNanoscale analysis of protein and peptide absorption: insulin absorption using complexation and pH-sensitive hydrogels as delivery vehicles.
Recent advances in the discovery and delivery of drugs to cure chronic diseases are achieved by combination of intelligent material design with advances in nanotechnology. Since many drugs act as protagonists or antagonists to different chemicals in the body, a delivery system that can respond to the concentrations of certain molecules in the body is invaluable. For this purpose, intelligent th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Pharmaceutics
سال: 2019
ISSN: 0378-5173
DOI: 10.1016/j.ijpharm.2019.03.013